Composition:

• Each 5 ml of Valprate syrup contains: 250 mg Sodium Valproate.
• Each prolonged-release film-coated tablets of Valprate contains: 333 mg Sodium valproate and 145 mg Valproic acid

(Equivalent amount of sodium valproate 500 mg)

Properties:

Valprate is from a group of medications called anti-epileptics or anti-convulsants.

Indications:

Valprate is used to control seizures in most types of epilepsy by increasing brain concentrations of gamma-aminobutyric acid (GABA).

Dosage:

• Valprate syrup:

The recommended initial dosage is 15 mg/kg/day, increasing at

one-week intervals by 5 to 10 mg/kg/day, until seizures are controlled. The maximum recommended dosage is 60 mg/kg/day, When the total daily dose exceeds 250 mg, it should be given in a divided regimen.

• Valprate tablets (for adults and children over 6 years of age and

weighing more than 17 kg):

The recommended initial dosage is between 1000 mg and 2000 mg per day, this dose may be increased to 2500 mg per day. It is generally divided into 1 to 2 doses per day, preferably during meals.

• Do not stop taking Valprate unless the doctor tells you.

Contraindications:

Valprate is not used in these cases:

• Hypersensitivity to Sodium Valproate, divalproate or valpromide.
• Hepatic disease.
• Mitochondrial disorders.
• Urea cycle disorders.

Side effects:

These side effects may occur such as:

• Headache, asthenia and fever.
• Nausea, vomiting, abdominal pain, diarrhea and dyspepsia.
• Somnolence, tremor, dizziness.
• Hair loss and skin rash.
• Irregular menses.

Precautions:

Tell your doctor before taking Valprate in these cases:

• Kidney disease
• Serious skin reactions
• Hepatotoxicity
• Pancreatitis
• Somnolence in the elderly
• Pregnancy and Breast-feeding
• Caution should be exercised during driving or operating machines
• Valprate can change the levels of liver enzymes, so the doctor may do regular liver function tests before and during the treatments. Drug interactions:

Tell your doctor if you take other medicines such as:

• Warfarin and Aspirin
• (Carbapenem) Antibiotics
• Rifampin
• Antacids
• Chlorpromazine
• Carbamazepine
• Clonazepam and Diazepam
• Herbal medicines
• Zidovudine and protease inhibitors such as Lopinavir or Ritonavir
• Monoamine oxidase inhibitors (MAOIs)

Package:

• Each bottle of Valprate syrup contains 120 ml
• Each box of Valprate tablets contains 30 Tablets

Storage:

• Keep the bottle tightly closed at a temperature below 30 C
• Keep in dry place and away from light