Composition:

Each tablet of Cartrand contains 6.25 mg Carvedilol

Properties:

Cartrand is a beta blocker and vasodilator. It widens blood vessels, lowers blood pressure and reduces the effort needed for the heart to pump blood around the body.

Indications:

Cartrand is used in these cases:

• Hypertension
• Angina (Chest pain)
• Heart failure

Dosage:

• Hypertension: The usual starting dose in adults is 12.5 mg once

a day for the first two days, then 25 mg once a day. If necessary, the

dose may be increased to a maximum of 50 mg daily.

In elderly the doctor may increase the dose more slowly.

• Angina: The usual starting dose is 12.5 mg twice a day for the first two days, then 25 mg twice a day. If necessary, the dose may be increased slowly to the maximum of 100 mg. The recommended maximum dose for elderly patients is 25 mg twice a day.
• Heart failure: The usual starting dose is 3.125 mg twice a day for two weeks. This dose may be increased in stages every two weeks. The maximum recommended dose is between 25 mg and 50 mg twice a day, depending on the weight. The maximum recommended dose in severe heart failure is 25 mg twice a day.
• If Cartrand treatment is stopped for more than two weeks, the

dose should be restarted at 3.125 mg twice daily and slowly

increased as above.

• In liver problems the doctor may decide a lower dose than those

stated above.

Contraindications:

Cartrand is not used in these cases:

• Hypersensitivity to Carvedilol
• Asthma or breathing problems due to other lung problems

• Unstable heart failure
• Cardiogenic shock

• Very slow heart beat or very low blood pressure

Side effects:

Cartrand can cause these side effects:

• Heart problems, the signs include chest pains, tiredness,

shortness of breath and swelling arms and legs

• Severe breathing difficulties including pneumonia
• Serious kidneys problems that may cause to urinate less, feel drowsy, breathless, weak or lose appetite

Precautions:

Tell your doctor before taking Cartrand in these cases:

• Heart failure including (low blood pressure or fluid retention)
• Ischaemic heart disease
• Kidney problems
• Diabetes
• Breathing problems
• Raynaud’s phenomenon (cold hands and feet)
• Acute inflammatory heart disease or obstruction of heart valves
• Orthostatic hypotension
• Serious allergic reaction or psoriasis
• Pregnancy and breast-feeding
• Children under 18 years old

Drug interactions:

Tell your doctor if you take other medicines:

• Medicines for heart or blood pressure including alpha blockers
• Other medicines which can cause lowering of blood pressure
• Carbamazepine
• Cinacalcet
• Bupropion
• Fuconazole
• Clonidine
• Antibiotics such as rifampicin or erythromycin
• Cimetidine

Package:

Each box of Cartrand contains 3 × 10 Tablets

Storage:

Store at a temperature below 30 C